Bath flanker Guy Pepper has been ruled out of England’s Nations Championship games next month and fly-half Santi Carreras will miss the rest of the season with a serious knee injury.

Pepper, 23, sustained an ankle injury in the second half of Bath’s 23-5 defeat at rivals Gloucester on Friday.

He has started 10 of England’s last 12 games but will not play against against Australia, Japan and New Zealand in November.

Carreras, 28, suffered an anterior cruciate ligament injury in the first half at Kingsholm and will play no part in Argentina’s Nations Championship games.

Pepper was not named in England head coach Steve Borthwick’s 36-player training squad on Sunday, which came after he sustained the injury.

Bath have since confirmed neither he nor Carreras will play any part in the Nations Championship.

But in a boost for the Prem club’s full-back options, Will Muir, Henry Arundell and Tom de Glanville have all resumed team training.

Back row Thompson Cowan and prop Billy Sela will also return to training in the coming weeks, with Sam Underhill expected to follow in early December.

Jamie Bhatti continues to work towards a return in the New Year, but Dan du Preez remains unavailable for selection.