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Blind-side flanker Holland Bogan and outside centre Rachel Phillips make their first Scotland starts as head coach Sione Fukofuka makes seven changes for Saturday’s Six Nations meeting with France in Edinburgh.
Leah Bartlett, Elis Martin, Louise McMillan, Becky Boyd and Rhona Lloyd return to the XV following a disappointing 41-14 loss to Italy.
Scotland opened with a narrow win in Wales and were crushed at home by defending champions England.
Captain Rachel Malcolm was injured shortly before kick-off in Parma, with fly-half Helen Nelson leading the side again in her absence.
Bartlett and Martin join the front row at loose-head prop and hooker, with lock McMillan winning her 60th cap.
Number eight Boyd makes her first start of this campaign, while winger Lloyd is back following concussion protocols.
Uncapped hooker Aicha Sutcliffe is among the replacements, along with Rhea Clarke, both featuring in their first matchday 23 of the tournament.
France have enjoyed comfortable victories over Italy, Wales and Ireland.
Scotland team to face France
Scotland: Chloe Rollie, Rhona Lloyd, Rachel Phillips, Meryl Smith, Francesca McGhie, Helen Nelson (capt), Leia Brebner-Holden; Leah Bartlett, Elis Martin, Elliann Clarke, Emma Wassell, Louise McMillan, Holland Bogan, Eva Donaldson, Becky Boyd.
Replacements: Aicha Sutcliffe, Demi Swann, Molly Poolman, Hollie Cunningham, Emily Coubrough, Rhea Clarke, Lucia Scott, Shona Campbell.
