For travelers looking for a retreat, Wake BioHotel in El Tesoro is the answer. Perched on a hill, expansive concrete interiors are softened by floor-to-ceiling windows, with leafy plants pressed up against them. Silo, the on-site restaurant, prides itself on using anti-inflammatory ingredients. There’s also a 24-hour gym, saltwater pool, infrared sauna, and cold plunges. The property is within walking distance of El Tesoro Parque Comercial and Amsterdam Plaza, which offer a host of dining options including 123 Wok, an Asian-Latin fusion restaurant, as well as Crepes & Waffles, a beloved Colombian chain.
Steps from El Poblado’s lively restaurant and nightlife scene and bordering the neighborhood of Provenza, Wake Medellín, Wake BioHotel’s newly opened sister property, brings the same wellness-first philosophy to the city’s core. The property’s brutalist and industrial exterior is matched with Japandi influences in its common spaces. Some of the amenities include a yoga room with classes available to guests throughout the week (except Sundays), a 24-hour gym, and a spa equipped with a sauna, cold plunge, and hydrothermal circuit. Opened in June 2026, the 128-room property is also home to a crop of ambitious new restaurants and bakeries. Among them is Boro, where Jaime David Rodríguez, the chef behind Cartagena’s highly acclaimed Celele, traces Colombia’s ecosystems through their menu. Guests are transported across the country through rainforest-inspired ingredients and Pacific-sourced seafood.
Another of Provenza’s stylish stays, 23 Hotel, draws inspiration from the tropics, using warm lighting and earthy textures to create a restorative ambience. The retro-modern architecture emphasized by circular bull’s-eye windows in each room makes it a unique stay in the city. After days out and about, make sure to catch sunset from the rooftop.
If you’re planning on sticking around for more than a couple of nights, Somos offers some of Medellín’s most design-forward apartment rentals. The group’s newest property, Somos LoHo, in the quieter neighborhood of San Lucas, features 18 two-bedroom apartments and a rooftop pool overlooking the city. On the ground floor of the property is Treat, a wellness-minded casual dining spot with gluten-free options. Don’t forget to try their hibiscus lemonade and their bowl acevichado, a mix of roasted salmon ceviche, avocado, peppers, marinated in coconut cream and served with rice and plantain.
